Job Description

The successful candidate will have outstanding expertise in mouse handling and mouse procedures. They will be responsible for managing mouse colonies, performing project-specific in vivo experiments, intravenous injections of hematopoietic stem cells in humanized murine models, retro-orbital and submandibular blood collection, and blood cell FACS analyses and in vivo imaging. This is a collaborative role that will be partnering with other team members to assist with project-specific- in vivo experiments as well as other needs across the process development function.

Role and Responsibilities:

• Hands-on role with a commitment to designing, conducting and analyzing in vivo studies to assess engraftment of hematopoietic stem cells
• Execute pluripotent stem cell culture and differentiation into hematopoietic stem cells to support process development, optimization, and characterization
• Document experimental procedures and results according to established guidelines; Perform statistical analysis of experimental data
• Collaborate effectively within departmental teams, engage in team discussions to resolve issues, and lead projects with a fully integrated team to facilitate successful outcomes
• Prior experience in bioreactor-based process development for iPSC-derived cell therapies is highly desirable

Qualifications:

• Advanced degree (M.S. or Ph.D.) in molecular biology or pharmacology, with at least 2 years of industry experience is required
• Experience working with human induced pluripotent stem cells (iPSC), hematopoietic stem cells (HSC), and/or immune cell biology; including scale-up processes utilizing bioreactors such as PBS vertical wheel, Rotea counterflow centrifuge is required
• Proficiency with in-vivo techniques including animal handling, intra-bone and intravenous transplants, blood collection and tissue dissection
• Experience in standard processing techniques including flow cytometry, molecular biology assays such as CFUs, immunological assays, and aseptic cell culture technique is required
• Experience with experiment design tools such as FlowJo and practical knowledge of statistical analysis is required
• Strong organizational, analytical, problem-solving, root-cause-analysis, and trouble-shooting skills are required

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